Fig. 6: Skp2-Akt signaling confers radioresistance of OSCC Cells.
From: E3 ligase Skp2-mediated stabilization of survivin contributes to radioresistance
A–D CAL27 cell-derived tumors were treated with IR. Tumor volume (A) and mice survival time (B) were recorded. Tumor tissues were collected and subjected to IHC staining (C, Scale bar, 20 μm). D Qualification of (C). ***p < 0.001. E–H CAL27 cell-derived tumors were treated with IR, MK2206, or combination. Tumor volume (E) and mice survival time (F) were recorded. Tumor tissues were collected and subjected to IHC staining (G, Scale bar, 20 μm). H Qualification of (G). **p < 0.01, ***p < 0.001.
