Fig. 1: MYC is highly expressed in G3 MB and significantly correlated with prognosis. | Cell Death Discovery

Fig. 1: MYC is highly expressed in G3 MB and significantly correlated with prognosis.

From: The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma

Fig. 1

A qRT-PCR revealed an increase of MYC in the mRNA level in G3 MB. B Western blot was used to detect the expression levels of MYC in adjacent non-tumor tissues and G3 MB. C IHC staining of patient clinical MB sample and adjacent non-tumor tissue. D The expression levels of MYC protein in different subtypes. E IHC staining of MYC in WNT, SHH, G3 and G4 MB. F The expression level of MYC is highly correlated with molecular typing, with high expression in G3 type (GSE164677). G-I Correlation analysis between MYC expression level and different clinical features, including gender, age and conventional pathological type. J Results of the Kaplan-Meier analysis of progression-free survival in different subtypes MB patients (GSE85218). K Kaplan-Meier analysis of the association between MYC expression levels and overall survival of G3 MB patients. L Western blot was used to detect the relative expression levels of MYC in six cell lines (SVG p12, Daoy, ONS76, D283, D341 and MB230524). NS p > 0.05, *p < 0.05, **p < 0.01, and ***p < 0.001.

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