Fig. 5: RIPK3 contributes to the activation of mitochondrial apoptotic pathway induced by UVB irradiation. | Cell Death Discovery

Fig. 5: RIPK3 contributes to the activation of mitochondrial apoptotic pathway induced by UVB irradiation.

From: UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity

Fig. 5

A Caspase-9 activity of HaCaT and GSK’872 pretreated HaCaT cells at 24 h after 60 mJ/cm2 UVB irradiation. Western blot analysis of B cleaved caspase-9, full-length caspase-9, and C cleaved caspase-3, full-length caspase-3 in HaCaT and GSK’872 pretreated HaCaT cells at 24 h after 60 mJ/cm2 UVB irradiation; and statistical analysis of the relative protein level of cleaved caspase-3. D Western blot analysis of bcl-2 and bax in HaCaT and GSK’872 pretreated HaCaT cells at 24 h after 60 mJ/cm2 UVB irradiation; and statistical analysis of the relative ratio of bcl-2/bax. Data are presented as mean ± SD, n = 3. P values determined by one-way analysis of variance (ANOVA), *P < 0.05, **P < 0.01.

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