Fig. 6: RIPK3 promotes UVB-induced epidermal necroptosis in mice. | Cell Death Discovery

Fig. 6: RIPK3 promotes UVB-induced epidermal necroptosis in mice.

From: UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity

Fig. 6

A Evaluation of dorsal skin lesions in WT (C57BL/6 J) and RIPK3-KO mice 48 h after UVB irradiation (500 mJ/cm²) or sham treatment, using a 12-point scoring system outlined in Table 1 (n = 6). B Histopathological analysis of dorsal skin from (A) using H&E staining, with representative images selected to illustrate key features (scale bar: 100 μm). C TUNEL assay of dorsal skin from mice in (A), providing representative images of epidermal cell apoptosis and quantification of apoptosis rate based on TUNEL-positive cells (n = 5). D Western blot analysis of p-RIPK3, p-MLKL, and p-NFκB in skin samples from (A) (n = 3). Data are presented as mean ± SD. P values determined by one-way analysis of variance (ANOVA), *P < 0.05, **P < 0.01.

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