Fig. 6: Treatment with rAAV9-Mgp alleviates osteoporosis and excessive adipogenesis in mice. | Cell Death Discovery

Fig. 6: Treatment with rAAV9-Mgp alleviates osteoporosis and excessive adipogenesis in mice.

From: MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis

Fig. 6

A Schematic of the timeline and workflow for the in vivo studies in mice to confirm the function of MGP. B Micro-CT scans were performed on coronal and horizontal sections of femurs from mice in the control group, mice with postmenopausal osteoporosis, and rAAV-9-Mgp-treated mice. Cortical bone and trabecular bone structure were analyzed through three-dimensional micro-CT reconstruction. C BV/TV, BS/BV, Tb.Sp, Ct.Th, Tb.N and Tb.Th were assessed in the control mice, mice with postmenopausal osteoporosis or rAAV-9 Mgp-treated mice. D H&E staining was performed on tissues from the control mice, mice with postmenopausal osteoporosis or rAAV-Mgp-treated mice. E The lipid level of each group was assessed by calculating the number and area of adipocytes. Scale bar = 250 μm. All the data are presented as the means ± SDs; n = 6 per group. Student’s t test or ANOVA was used to determine significant differences. ns not statistically significant; *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001.

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