Fig. 1: C12ORF49 expression is significantly elevated and its higher level predicts poor patients’ survival in HCC. | Cell Death Discovery

Fig. 1: C12ORF49 expression is significantly elevated and its higher level predicts poor patients’ survival in HCC.

From: C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism

Fig. 1

A qRT-PCR assay for C12ORF49 expression in paired cancerous and adjacent non-cancerous tissues from a cohort of 30 HCC patients. B UALCAN analysis was conducted to compare C12ORF49 expression in human HCC tissues versus non-tumorous liver tissues. C12ORF49 expression was assessed in indicated cells through qRT-PCR (C) and western blot (D) assays. E Immunohistochemical (IHC) staining of C12ORF49 was performed on a larger cohort of 238-paired cancerous and adjacent non-cancerous tissues (Scale bar = 20 µm). Comparison of overall survival (F) in C12ORF49 high or low expression HCC patients (n = 238). G Comparison of recurrence-free survival in C12ORF49 high or low expression HCC patients (n = 238). H Prognostic relevance of C12ORF49 in HCC was evaluated through bioinformatics analysis using the UALCAN platform.

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