Fig. 3: The suppressive effect of C12ORF49 silencing on HCC growth was confirmed in mouse models. | Cell Death Discovery

Fig. 3: The suppressive effect of C12ORF49 silencing on HCC growth was confirmed in mouse models.

From: C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism

Fig. 3

A Subcutaneous implantation nude mice models were constructed in indicated groups. B Representative images and weight of tumors dissected from subcutaneous xenograft models. C, D C12ORF49 and Ki-67 expressions were assessed by IHC assay to assess the efficiency of C12ORF49 knockdown and its impact on cell proliferation (Scale bar = 50 µm). E TUNEL assay was employed to assess the impact of C12ORF49 knockdown on in vivo cell apoptosis (Scale bar = 50 µm). F The impact of C12ORF49 knockdown on in vivo lung metastatic capabilities of HLF cells was assessed in nude mice models (Scale bar = 50 µm).

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