Fig. 8: C12ORF49 silencing enhances the efficiency of sorafenib treatment on the suppression of HCC growth and induction of ferroptosis. | Cell Death Discovery

Fig. 8: C12ORF49 silencing enhances the efficiency of sorafenib treatment on the suppression of HCC growth and induction of ferroptosis.

From: C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism

Fig. 8

A Cell death in HLF and HLE cells was evaluated. Sorafenib (10 μM). Quantifications of lipid ROS (B) and Fe2+ (C) in HLF and HLE cells (Scale bar = 20 µm). MTS (D) and colony (E) assays in HLF and HLE cells. F, G qRT-PCR and WB assays were conducted to determine C12ORF49 expression in Sorafenib-resistant or -sensitive HLF and HLE cells. Values are expressed as mean ± SEM from three individual experiments (n = 3).

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