Fig. 2: Domain structure of NRF2 and its regulatory interactions. | Cell Death Discovery

Fig. 2: Domain structure of NRF2 and its regulatory interactions.

From: Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Fig. 2

The Neh2 domain binds Keap1 via the DLG and ETGE motifs, regulating NRF2 stability. Neh4 and Neh5 facilitate transcriptional activation by interacting with co-activators such as HRD1 and CBP. Neh7 inhibits NRF2 via interaction with RXRα, Neh6 promotes degradation through the DSGIS and DSAPGS motifs, interacting with β-TrCP and GSK3β. The Neh1 domain contains the CNC-bZIP motif for DNA binding and dimerization, and Neh3 supports transcriptional activation.

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