Fig. 1: METTL13 was upregulated and associated with poor prognosis of AML.
From: METTL13 is essential for the survival of acute myeloid leukemia cells by regulating MYC
A Expression level of METTL family in AML patients from TCGA database. The members confirmed to promote AML progression in other research were marked in blue (METTL1/3/14/16), while the focus in this study, METTL13, was marked in red. B Expression of METTL13 in healthy individuals, clinical AML patients and cell lines. C Expression of METTL13 in AML and non-matched normal samples in the TCGA and GTEx databases. D Western blotting using normal bone marrow of healthy individuals and AML patients, and cell lines (HL-60, K562, U937, MOLM-13, MV-4-11, KG1a and Kasumi-1). Fluorescence intensity was quantified by Fiji software. E Correlation between METTL13 and overall survival of AML patients from GEPIA database (http://gepia.cancer-pku.cn). Data were presented as mean ± SD (Student’s test, *p < 0.05, ***p < 0.001).
