Fig. 5: Transcriptomic alterations in leukemia cells after METTL13 knockdown.
From: METTL13 is essential for the survival of acute myeloid leukemia cells by regulating MYC
A Pearson correlation analysis on the whole-genome transcriptome of HL-60 and K562 cells after METTL13 knockdown. B Venn diagrams illustrate the number of genes co-upregulated or co-downregulated after METTL13 knockdown using two different shRNA in HL-60 and K562 cells, respectively (left panel). These genes were presented in heatmaps (right panel). C The Venn diagram illustrates genes co-downregulated in HL-60 and K562 cells after METTL13 knockdown. D GO analysis (BP) of signaling pathways enriched in co-downregulated genes in panel C. E and F Validation of the expression level of MYC by RT-qPCR and western blot in HL-60 and K562 cells. Data were presented as mean ± SD (Student’s test, *p < 0.05, **p < 0.01, ***p < 0.001).
