Fig. 1: Ndufs6 knock out in heart tissue could develop cardiomyocyte in mice.
From: Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency
A Procedure for identification of Ndufs6gt/gt mice. B Representative images of left ventricular echocardiograph in WT and Ndufs6gt/gt mice and M-mode echocardiograph data (EF% and FS%) of left ventricle in WT and Ndufs6gt/gt mice (n = 6). C Representative images of heart and cardiac cross section with H&E staining from WT and Ndufs6gt/gt mice, followed by statistical analysis of LVEDD and HW/BW (n = 6). Scale bar = 1 mm. D Representative images of Masson’s trichrome staining and quantitative measurement of heart fibrosis (n = 6). Scale bar = 100 μm. E Representative images of mitochondrial ultrastructure and quantification of mitochondrial fragmentation (n = 6). Scale bar = 2 μm. F Representative images of mitochondrial cristae and the quantification of the degree of cristae damage (n = 6). Scale bar = 500 nm. G Mitochondrial CI activity of WT and Ndufs6gt/gt group (n = 6). H Survival rate of WT and Ndufs6gt/gt groups (n = 15).
