Fig. 4: Administration of AAV9-hNdufs6 prevented cardiomyopathy in Ndufs6gt/gt mice via the AMPK pathway.
From: Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency
A Cardiac mitochondrial CI activity results of WT, Ndufs6gt/gt, and AAV-Neonatal groups (n = 6). B Protein expression levels of p-Drp1, Drp1, p-AMPK and AMPK in cardiac tissue (expressed as relative fold, normalized to β-Actin and followed by normalization to WT gray scale/ β-Actin gray scale) were analyzed in the WT, Ndufs6gt/gt, and AAV-Neonatal groups (B, C). Quantitative assessment of p-Drp1/Drp1 (B) and p-AMPK/AMPK (C) expressions in WT mice, Ndufs6gt/gt and AAV-Neonatal mice is presented (n = 4). D DHE staining for ROS and quantification are illustrated (n = 4). Scale bar = 50 μm.
