Fig. 1: SOX4 is overexpressed in HCC and correlates with angiogenesis. | Cell Death Discovery

Fig. 1: SOX4 is overexpressed in HCC and correlates with angiogenesis.

From: SOX4 reprograms fatty acid metabolism through the CHREBP to inhibit ferroptosis in hepatocellular carcinoma

Fig. 1

A, B SOX4 mRNA levels are significantly higher in HCC tumor tissues compared to normal tissues based on TCGA and GSE144269 datasets. C Elevated SOX4 levels were detected in the plasma of HCC patients using GSE142987. D Analysis of paired tumor and adjacent non-tumor tissues confirmed high SOX4 expression in tumor tissues using clinical samples. E Single-cell transcriptomics analysis (GSE12544, GSE14611) shows predominant SOX4 expression in malignant cells. F Western blot analysis validates elevated SOX4 protein levels in tumor tissues. G Kaplan–Meier survival curves from TCGA demonstrate poorer survival in patients with high SOX4 expression. H, I Gene Set Variation Analysis (GSVA) reveals a significant association between SOX4 and the angiogenesis hallmark. *P < 0.05, **P < 0.01, ***P < 0.001.

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