Fig. 3: SOX4 drives fatty acid metabolism reprogramming in HCC. | Cell Death Discovery

Fig. 3: SOX4 drives fatty acid metabolism reprogramming in HCC.

From: SOX4 reprograms fatty acid metabolism through the CHREBP to inhibit ferroptosis in hepatocellular carcinoma

Fig. 3

A RNA-sequencing identifies differentially expressed genes upon SOX4 knockdown (2248 upregulated and 1748 downregulated). B, C GO and KEGG analyses highlight significant enrichment in fatty acid metabolism pathways. D, E Nile Red staining shows decreased lipid droplet accumulation in SOX4 knockdown cells and increased accumulation in overexpressing cells. F, G Intracellular triglyceride and cholesterol levels are significantly altered by SOX4 modulation. H, I GC–MS analysis confirms reduced fatty acid levels in SOX4 knockdown cells and increased levels in overexpressing cells. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page