Fig. 3: miR-139-5p inhibits cholesterol synthesis in glioma cells by decreasing the expression of HMGCR. | Cell Death Discovery

Fig. 3: miR-139-5p inhibits cholesterol synthesis in glioma cells by decreasing the expression of HMGCR.

From: miR-139-5p activates ferroptosis by inhibiting the expression of HMG-CoA reductase to inhibit the progression of glioma

Fig. 3

A Differential gene cluster heat maps in transcriptome sequencing showed downregulated expression of genes related to cholesterol biosynthesis such as HMGCR in miR-139-5p overexpressed glioma cells. B–E GSEA gene set enrichment analysis revealed that genes after miR-139-5p mimic treatment were mostly enriched in gene sets downregulating cholesterol biosynthesis and other pathways. F The differential gene volcano map indicates that the expression of HMGCR in miR-139-5p overexpressed cells was downregulated. G, H Differential gene GO enrichment bubble map and differential gene KEGG enrichment bubble map showed that miR-139-5p overexpressing cells were enriched in the cholesterol metabolism pathway. Data are presented as mean ± standard deviation (SD) from three independent experiments. ***p < 0.001, **p < 0.01, *p < 0.05.

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