Fig. 4: RGS3 knockdown inhibits tumor proliferation in vivo. | Cell Death Discovery

Fig. 4: RGS3 knockdown inhibits tumor proliferation in vivo.

From: RGS3 acts as a tumor promoter by facilitating the regulation of the TGF-β signaling pathway and promoting EMT in ovarian cancer

Fig. 4

A–D Western blot analysis of infection efficiency in SKOV3 and OVCAR8 cells with lentiviral constructs. E, F Xenograft tumor growth and size comparison between RGS3 knockdown and overexpression groups. G–J Xenograft tumor volume and weight comparison between RGS3 knockdown and overexpression groups. K, L The expression of Ki-67 and RGS3 was measured in IOD. M Representative immunohistochemical images of RGS3 and Ki-67 expression. Data analyzed using Student’s t-test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, (scale bars: 200 μm, 100 μm).

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