Fig. 5: The combination of PRMT5 and MAT2A inhibitors produces synthetic lethal effects in glioma organoid models. | Cell Death Discovery

Fig. 5: The combination of PRMT5 and MAT2A inhibitors produces synthetic lethal effects in glioma organoid models.

From: Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models

Fig. 5

A Immunofluorescence assay to determine MTAP expression in 2 glioblastoma organoids, and their statistical charts (scale bar: 200 μm) (n = 3). B Flowchart of organoid experiments. C, D Brightfield images showing the cellular state of organoids after treatment with the inhibitors at 7 days and 14 days (scale bar: 200 μm). E, F H&E staining and immunohistochemical staining of SDMA, Ki67, γ-H2AX using paraffin sections of glioblastoma organoids after 14 days of co-culture (scale bar: 200 μm).

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