Fig. 6: Inhibitors can significantly improve survival time and reduce tumor burden in nude mouse models in vivo. | Cell Death Discovery

Fig. 6: Inhibitors can significantly improve survival time and reduce tumor burden in nude mouse models in vivo.

From: Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models

Fig. 6

A Flowchart of animal experiments. B Representative bioluminescence images of 4 groups of mice injected with cells (Vehicle, AM193 [100 mg/kg, PO, QD], PRMT5 inhibitor [100 mg/kg, PO, QD], combination of the PRMT5 inhibitor [100 mg/kg, PO, QD] and MAT2A inhibitor [5 mg/kg, PO, QD]). C Survival analysis of the 4 groups. D Bioluminescence analysis of the 4 groups. E Body weight analysis of the 4 groups. F H&E staining and immunohistochemical staining (Ki67, SDMA) of the brain sections of mice (scale bar: 100 μm).

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