Fig. 4: Fibroblast-specific depletion of UHRF1 inhibits UIR-induced renal fibrosis. | Cell Death Discovery

Fig. 4: Fibroblast-specific depletion of UHRF1 inhibits UIR-induced renal fibrosis.

From: Inhibition of epigenetic regulator UHRF1 attenuates renal fibrosis and retains transcription factor Krüppel-like factor 15 expression

Fig. 4

Col1a2-Cre+/UHRF1flox/flox mice (fibroblast-specific depletion of UHRF1) and their littermate controls received Sham or UIR operation for 14 days. A Illustration of experimental design to induce fibroblast-specific depletion of UHRF1 in UIR mice. B Immunofluorescence double-labeling with antibodies to UHRF1 (Red) and PDFGRα + β (green) (×200). The white arrow represents UHRF1+ fibroblasts. Scale bar: 50 μm. C, D Masson staining and immunochemistry staining for α-SMA and Fibronectin in kidney sections (×200). Scale bar: 100 μm. n = 6 mice per group. Data were shown as mean ± SEM. Data were analyzed using One-way ANOVA followed by Tukey. *P < 0.05, **P < 0.01.

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