Fig. 3: Ppif inhibits natural disease progression in M/D-driven mammary carcinomas. | Cell Death Discovery

Fig. 3: Ppif inhibits natural disease progression in M/D-driven mammary carcinomas.

From: CYPD limits HR+ mammary carcinogenesis in mice

Fig. 3

Wild-type (WT) Ppif−/−, Ripk3−/− or Mlkl−/− female C57BL/6J mice were subjected M/D-driven carcinogenesis and analyzed as illustrated in Fig. 1A. Time to death (TTD) (A), cumulative tumor growth (B), relative contribution of primary tumors (T1) to overall disease burden at euthanasia (C) and overall survival (OS) (D) are illustrated. In (A and D) median values, Mantel–Haenszel hazard ratio (HR) with 95% confidence interval (CI), group size (n), and p values (Log-rank) are indicated. Mice succumbing to causes other than euthanasia owing to global disease burden were censored from the analysis. In (B) both individual and average tumor growth are illustrated, with group size (n) and p values (2-way ANOVA, compared to WT mice) reported. In (C) results are reported as means ± SEM and individual data points, p values (Kruskal–Wallis, compared to WT mice) are indicated.

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