Fig. 7: Transcriptome analysis of lung tissues from mice treated with poly(I:C).
From: Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation
A Volcanic map describes DEGs between the samples of the virus-induced lung injury and control group. Red, blue, and gray dots represent gene expression levels associated with upregulation, downregulation, and no significant expression, respectively. B Heat map showed the top 5 up-regulated and down-regulated DEGs. C GSEA analysis showed that NOD like receptor signaling pathway was significantly enriched in the virus-induced lung injury. D The top 20 pathways with significant differences in GSVA. E Hub genes obtained from the PPI network, including Ccxl5 and Nlrp3. F Co-expression network diagram of hub genes. G, H GO and KEGG analysis of co-expressed hub genes.
