Fig. 9: Hippo/NLRP3/IL-1β pathway is activated in patients with viral pneumonia.
From: Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation
A Hippo pathway expression in mononuclear macrophages isolated from peripheral blood of patients with viral pneumonia and healthy individuals. B Relative expression of YAP protein in mononuclear macrophages isolated from peripheral blood of patients with viral pneumonia and healthy individuals was assessed after nuclear-plasma separation. C NLRP3 expression in mononuclear macrophages isolated from peripheral blood of patients with viral pneumonia and healthy individuals. D Evaluation of IL-1β levels in mononuclear macrophages isolated from peripheral blood of patients with viral pneumonia and healthy individuals. All data are representative as means ± s.e.m of three independent experiments. Student’s t test for (A–I); *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Scale bar = 20 μm.
