Fig. 1: The identification of the differentially expressed mRNAs and miRNAs that possess prognostic significance in colorectal cancer. | Cell Death Discovery

Fig. 1: The identification of the differentially expressed mRNAs and miRNAs that possess prognostic significance in colorectal cancer.

From: DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy

Fig. 1

A–C Differentially expressed mRNA volcano plot |(log2(fold change)| ≥1.5 or ≤1.5; adj. p < 0.05). Blue dots: significantly downregulated (Down); red dots: significantly upregulated (Up); gray dots: no significant differences (NS). D The Venn diagram shows the intersection of downregulated genes in three datasets. E The PPI network shows the top 20 hub genes of significantly downregulated genes. F Construction of a miRNA-mRNA network. The blue and red ellipses represent miRNA. The green diamond indicates downregulated hub mRNA. G The volcano plot of differentially expressed miRNAs |log2(fold change)| ≥ 1 or ≤1; adj. p < 0.05). H Venn diagram shows the intersection between target prediction miRNA (upstream miRNAs of downregulated hub genes) and TCGA upregulated miRNAs. I The co-expression analysis of miRNA-mRNA interaction pairs. J Overall survival of four miRNA in TCGA-COAD/READ cohort.

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