Fig. 3: Downregulation of PGC1α and prognostic significance in CRC. | Cell Death Discovery

Fig. 3: Downregulation of PGC1α and prognostic significance in CRC.

From: DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy

Fig. 3

A PGC1α expression in paired samples of tumor tissues and nontumorous adjacent normal colorectum tissues from patients with CRC in the TCGA and three GSE cohorts. B, C mRNA levels of PGC1α were evaluated using quantitative real-time PCR in 121 paired samples from patients with CRC. D Eight paired samples from patients with CRC were analyzed by Western blot. E Immunohistochemical staining for PGC1α was performed on patients with CRC. F Kaplan–Meier analysis for OS was performed according to PGC1α mRNA levels. **P < 0.01 indicates significant differences from the normal group as assessed by the Wilcox test.

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