Fig. 4: CRC proliferation is suppressed by PGC1α in vitro and in vivo. | Cell Death Discovery

Fig. 4: CRC proliferation is suppressed by PGC1α in vitro and in vivo.

From: DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy

Fig. 4

A, B Cell viability of CRC cells with PGC1α overexpression or knockdown compared with the control vector group was analyzed using the CCK-8 assay (n = 3). C, D Effects of CRC cells with PGC1α overexpression and knockdown on colony formation compared with control vector group (n = 4). E, F Effects of CRC cells with PGC1α overexpression and knockdown on EDU assay (n = 3). G Image of tumors isolated from nude mice with tumor xenografts derived from the indicated groups. Effects of PGC1α overexpression or knockdown on tumorigenicity in nude mice. H Tumor volumes were monitored at indicated time points. I The tumor weight was measured at euthanasia time (n = 5). Values are presented as mean ± SD. *P < 0.05 or **P < 0.01 indicates significant differences from the vehicle group as assessed by a one-way ANOVA with a post hoc Dunnett’s test.

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