Fig. 4: MUC1 gene promoter modulation by AR and STAT3. | Cell Death Discovery

Fig. 4: MUC1 gene promoter modulation by AR and STAT3.

From: Decoding MUC1 and AR axis in a radiation-induced neuroendocrine prostate cancer cell-subpopulation unveils novel therapeutic targets

Fig. 4

AR (A, B) and γ-STAT3 (C, D) % input values at MUC1 gene promoter in three different regions above transcription starting site (TSS) for 22Rv1-RR (radioresistant) compared to 22Rv1-P (parental) cells and for PC3-NC and PC3-AR (AR overexpressing cells), respectively. Graphs were represented by mean ± standard deviation (SD) values. *p-value < 0.05, **p-value < 0.01; ****p-value < 0.0001. E Representative scheme of MUC1 gene promoter regulation by AR (Blue) and γ-STAT3 (green) binding. AR expression in 22Rv1-P and PC3-AR leads to MUC1 transcriptional repression, while AR downregulation in 22Rv1-RR and PC3-NC leads to MUC1 transcriptional activation.

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