Fig. 3: Sufu prevents sepsis by disrupting the LLPS of TRAF6.
From: Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis
Left panel: Physiologically, TRAF6 is dispersed in the cytoplasm and does not mediate inflammation by effectively activating the transcription of NF-κB signalling. Right panel: Upon the activation of LPS signalling, TRAF6 condenses through the mechanism of LLPS, a previously undefined phenomenon. In addition, Sufu, an important member of the Hh signalling pathway, negatively regulates TLR-related inflammatory damage by disrupting the LLPS and droplet formation of TRAF6 upon LPS signalling. TRAF6 autoubiquitination and oligomerization are required for TRAF6 LLPS.
