Fig. 5: LLPS regulates immune cell alterations during adaptive immunity. | Cell Death Discovery

Fig. 5: LLPS regulates immune cell alterations during adaptive immunity.

From: Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis

Fig. 5

SLP65 drives tripartite LLPS, forms droplets with CIN85 and SUVs, and activates BCR signalling pathways. Tripartite LLPS requires the interaction between the CIN85 SH3 domain and SLP65 proline-rich motifs and the preference of the lipid-binding domain for high-membrane-curvature SUVs. LAT phosphorylation drives LLPS and forms macromolecule condensates with Grb2 and SOS to trigger TCR signalling pathways. This figure was created with BioRender.com.

Back to article page