Fig. 5: Proteomics characterization of PNI cells. | Cell Death Discovery

Fig. 5: Proteomics characterization of PNI cells.

From: Defining the cellular and molecular features of nerve-invaded cancer cells using a newly characterized experimental model

Fig. 5

A Combined brightfield and fluorescence image of a droplet of FACS-sorted PNI cells shows the purity of the isolated cells (white arrows). B PANTHER GO analysis shows the enriched molecular functions of proteins downregulated in PNI cells. C STRING analysis shows protein interaction network of CPLANE1, hemopexin and SANBR. D A representative image of a hematoxylin and eosin (H&E) stained human breast tumor sample showing PNI (red arrows; the cyan asterisks indicate nerves) (scale bar, 50 µm). E CPLANE mRNA levels in PNI+ and PNI- human breast tumor samples (n = 4; Student’s ‘t’ test, *p < 0.05). F Hemopexin mRNA levels in PNI+ and PNI- human breast tumor samples (n = 3; Student’s ‘t’ test). G Representative images of a section of DRG-nerve preparation from 2-week-old in vitro PNI model show the expression of hemopexin in PNI cells (scale bar, 50 µm).

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