Fig. 2: Post-translational modification landscape of human CYP51A1.
From: CYP51A1 in health and disease: from sterol metabolism to regulated cell death
This figure illustrates the distribution and frequency of experimentally validated post-translational modifications (PTMs) along the amino acid sequence of human CYP51A1. The x-axis denotes residue position, and the y-axis indicates the log2 (total number of references) reporting a specific P 509 amino acids TM site (from both high-throughput and low-throughput studies). PTMs are color-coded by type: phosphorylation (blue), ubiquitylation (orange), and other modifications (gray). Functional domains are annotated at the bottom: the transmembrane region (TM) and the conserved cytochrome P450 catalytic domain (p450). Notably, several high-frequency ubiquitylation sites are located within the p450 domain, suggesting possible regulation of CYP51A1 activity or stability via the ubiquitin-proteasome system (Data from https://www.phosphosite.org/).
