Table 2 The role of aberrant CYP51A1 expression in diseases.
From: CYP51A1 in health and disease: from sterol metabolism to regulated cell death
Diseases | Expression and role | Mechanism | Model | Refs. |
|---|---|---|---|---|
Cancer | Upregulation; Promotion | Providing raw materials required for biofilm synthesis in cancer cells or remodeling the tumor microenvironment via the substrate lanosterol | Various cancer cell and mice | |
Cataracts | Mutation, upregulation or downregulation; Promotion | Mechanism unknown, may involve cholesterol metabolism disorder | Mice and patients | |
Antley-Bixler syndrome | Mutation or deletion; Promotion | Accumulation of endogenous substrates and lack of products | Mice | |
Neurodegenerative disease | Upregulation; Inhibition | Increase lanosterol and delay disease progression by inducing mild mitochondrial depolarization and promoting autophagy | Cos-7 and A549 cells; mice | |
Autoimmune disease | Upregulation; Promotion | Accumulation of endogenous substrates and lack of products | Oligodendrocyte; mice | |
Metabolic damage diseases | Downregulation; Promotion | Cholesterol deficiency | Mice | [95] |
