Fig. 1: The correlation between the expression of D2-40 (+) lymphatic vessels and modified NIH activity indexes and serum anti-dsDNA antibody levels. | Cell Death Discovery

Fig. 1: The correlation between the expression of D2-40 (+) lymphatic vessels and modified NIH activity indexes and serum anti-dsDNA antibody levels.

From: Inhibition of VEGFR-3 by SAR131675 decreases renal inflammation and lymphangiogenesis in the murine lupus nephritis model

Fig. 1

Representative sections of human kidney tissues that were pathologically diagnosed with LN (class I to V, n = 22) were immunohistochemically stained with D2-40, a human lymphatic vessel marker, with magnification of 100× and 200×. Scale bar = 100 μm. D2-40(+) lymphatic vessels were counted in magnification of 200×. Each section shows the lupus class I, III, IV, and V with modified NIH activity indexes. Significant correlations were observed between the modified NIH activity indexes of LN and D2-40 (+) lymphatic vessel expression (Spearman’s ρ = 0.517, P = 0.014; Kendall’s τ = 0.434, P = 0.008), as well as serum anti-dsDNA antibody levels and D2-40 (+) lymphatic vessel expression (Spearman’s ρ = 0.581, P = 0.005; Kendall’s τ = 0.389, P = 0.014). LN, lupus nephritis.

Back to article page