Fig. 1: SPON2 expression is upregulated in OS and correlates with poor prognosis. | Cell Death Discovery

Fig. 1: SPON2 expression is upregulated in OS and correlates with poor prognosis.

From: SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis

Fig. 1

A, B mRNA and protein expression of SPON2 in OS cell lines (MG63 and 143B) compared to the normal osteoblast cell line hFOB1.19. Data show a significant increase in SPON2 expression in OS cells. Data are shown as mean ± SD (n = 3 biological replicates). Statistical analysis was performed using one-way ANOVA followed by Tukey’s post-hoc test. **p < 0.01. C Survival analysis indicates that higher SPON2 expression correlates with shorter overall survival in OS patients. D The mRNA expression of SPON2 in tumor and normal tissue samples was examined by analyzing TCGA database. The Unpaired Wilcoxon Rank Sum and Signed Rank Tests were employed. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns: not significant. E Survival analysis of SPON2 in TCGA dataset.

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