Fig. 5: Basophils are recruited and enhance Il1b expression in an AD mouse model. | Cell Death Discovery

Fig. 5: Basophils are recruited and enhance Il1b expression in an AD mouse model.

From: IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation

Fig. 5

A Publicly available scRNA-seq data (GSE149121) were reanalyzed. UMAP plot of the control (ethanol-treated) and OXA-treated skin samples are shown. Colors represent different Seurat clusters. B Violin plots showing the expression of Gata2 in control and OXA-treated skin samples are shown. C Violin plots showing the expression of Mcpt8, Mcpt4, Cma1, and Tpsb2 in control and OXA-treated skin samples are shown. D The ratios of basophils and mast cells in the ear skin samples are shown (n = 3). Data are expressed as dot plots with the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. E Violin plots showing the expression of Il1rl1, Nlrp3, and Il1b in control and OXA-treated skin samples are shown.

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