Fig. 6: MAP2K2 knockdown attenuates the promotion of EIF3B overexpression to tumor growth. | Cell Death Discovery

Fig. 6: MAP2K2 knockdown attenuates the promotion of EIF3B overexpression to tumor growth.

From: EIF3B stabilizes MAP2K2 to activate the ERK pathway and promote the progression of laryngeal squamous cell carcinoma

Fig. 6

A–D After injecting AMC-HN-8 cells (NC, EIF3B, shMAP2K2, EIF3B+ shMAP2K2) into the mouse xenograft model, the fluorescence intensity (A), tumor volume (B, C), and tumor weight (D) were detected respectively. E The tumor tissues of each group of mice were stained with hematoxylin and eosin (H&E) and IHC staining to identify the Ki67 expression in tumors. F Quantification of Ki67 immunohistochemical staining in tumor sections from different groups. The data were presented as the mean ± SD (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001.

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