Fig. 5: A schematic representation of the crucial function of Hippo signaling pathway in diabetes. | Cell Death Discovery

Fig. 5: A schematic representation of the crucial function of Hippo signaling pathway in diabetes.

From: The Hippo signaling pathway modulates pancreatic tissue homeostasis

Fig. 5

External stimuli activate MST1/2 in β-cell and trigger the phosphorylation of downstream effectors, such as PDX1, LATS1/2 and YAP/TAZ. These phosphorylated kinases further lead to diabetes by either interacting with other signaling pathways (e.g., AKT-JNK pathway, mTOR pathway) to promote β-cell apoptosis or inhibiting the normal function of PDX1, which is responsible for insulin production.

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