Fig. 1: Transcriptional signatures of different striatal regions.

A Schematic diagram of the joint analysis of multi-omics data from the normal group and PD group. Principal component analysis (B) and DEGs (C) of transcriptome data of CAU from normal group and PD group. D Heat map shows the expression patterns of DEGs of the transcriptome data of CAU in the normal group and PD group, and some genes of interest are listed on the right. E KEGG analysis of DEGs based on CAU and PUT transcriptome data. GSEA analysis of CAU transcriptome data based on the relevant GO term gene list (F) and KEGG pathway gene list (G).