Fig. 2: Mitochondrial dysfunction is a concomitant cellular injury phenotype in PD. | Cell Death Discovery

Fig. 2: Mitochondrial dysfunction is a concomitant cellular injury phenotype in PD.

From: Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson’s disease through inhibition of H3K4me3 demethylation

Fig. 2

A Venn diagram shows the overlapping genes among CAU DEGs, PUT DEGs and mitochondrial-related genes. KEGG analysis (B) and GO analysis (C) based on overlapping genes. D Cell viability analysis of SH-SY5Y cells treated with MPP+ at the indicated times and concentrations. Data are mean ± SEM; n = 4 biological replicates. E Schematic diagram of the establishment of the PD cell model. F Bright field images of cells in the PD cell model. G Representative images (left) and ratios (right) of TUNEL+ cells in PD cell model. Data are mean ± SEM; n = 6 biological replicates. H Representative images of flow cytometric analysis of MMP in PD cell model (left), median fluorescence intensity (MFI; middle), and the proportion of high MMP (H-MMP) to total cell number (right). Data are mean ± SEM; n = 9 biological replicates. I ATP levels in PD cell model. The upper and lower boundary in the plot indicates the upper and lower quantiles, the line inside the plot the median; n = 15 biological replicates. J TOMM20 protein expression level in PD cell model. Data are mean ± SEM; n = 7 biological replicates. K mRNA expression levels of TCA cycle and OXPHOS-related genes in PD cell model. Data are mean ± SEM; n = 4 biological replicates.

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