Fig. 3: Targeting the MQC system restore mitochondrial function and alleviate cell damage in PD cell in vitro model. | Cell Death Discovery

Fig. 3: Targeting the MQC system restore mitochondrial function and alleviate cell damage in PD cell in vitro model.

From: Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson’s disease through inhibition of H3K4me3 demethylation

Fig. 3

A Schematic diagram of the MQC system. Representative images (B) and expression level analysis of proteins related to the MQC system in PD cell model, including mitochondrial biogenesis (C), autophagy (D) and dynamics (E). Data are mean ± SEM; n = 5 to 10 biological replicates. F Cell viability analysis of PD cell model treated with ZLN005 at the indicated concentrations. Data are mean ± SEM; n = 4 biological replicates. G Cell viability analysis of PD cell model treated with GSK3-IN-3 at the indicated concentrations. Data are mean ± SEM; n = 4 biological replicates. H Schematic diagram of the establishment of the cell model treated with ZLN005 and GSK3-IN-3. I Bright field images of PD cell model treated with ZLN005 and GSK3-IN-3. J Representative images of flow cytometric analysis of MMP (left) and MFI (right) in PD cell model treated with ZLN005 and GSK3-IN-3. Data are mean ± SEM; n = 4 biological replicates. K Representative images (left) and ratios (right) of TUNEL+ cells in PD cell model treated with ZLN005 and GSK3-IN-3. Data are mean ± SEM; n = 5 biological replicates.

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