Fig. 2: AMG487 improved neurological dysfunction and decreased brain edema following ICH. | Cell Death Discovery

Fig. 2: AMG487 improved neurological dysfunction and decreased brain edema following ICH.

From: Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Fig. 2

A–C The modified Garcia test, the left turn test and the forelimb placement test with different concentrations of AMG487 treatment at 24 h and 72 h post-ICH. D Brain water content after treatment with different concentrations of AMG487. E–G The modified Garcia test, the left turn test and the forelimb placement test with AMG487 treatment at 72 h post ICH. H Brain water content after treatment with AMG487 at 72 h post ICH. I Typical tracks of water maze exploration. J–L Escape latency, prob quadrant duration and frequence cross the platform, n = 6. *P < 0.05 vs. sham; #P < 0.05 vs. ICH+vehicle; ns: no significant.

Back to article page