Fig. 3: Differential expression gene and functional enrichment analysis of the ICH mice and ICH + AMG487 mice. | Cell Death Discovery

Fig. 3: Differential expression gene and functional enrichment analysis of the ICH mice and ICH + AMG487 mice.

From: Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Fig. 3

A Principal components analysis of DEGs between ICH and ICH + AMG487 mice. B volcano plot of DEGs between the ICH and ICH + AMG487 mice. C The clustering results are presented in a trend heatmap. The left section displays the results of the trend clustering, while the middle section shows the heatmap of gene expression across the four clusters (C1, C2, C3, and C4). The right section is divided into three smaller parts from left to right: the first part indicates the number of genes contained in each cluster (C1, C2, C3, C4); the second part presents the biological processes associated with each cluster along with their corresponding log10 p-value; and the third part summarizes the KEGG enrichment analysis results for each cluster along with their corresponding log10 p-value. D GSEA enrichment analysis of NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway and NF-Kappa B signaling pathway.

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