Fig. 9: A151 treatment improved vascular endothelial cell integrity and mitigated BBB disruption in mice. | Cell Death Discovery

Fig. 9: A151 treatment improved vascular endothelial cell integrity and mitigated BBB disruption in mice.

From: Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Fig. 9

A mRNA expression levels of cGAS and AIM2 in the perilesional tissue of the hemorrhagic brain, n = 6. B, C Representative western blot bands and quantitative analyses for cGAS, STING, AIM2, ASC, Caspase-1, and GSDMD in the perihematomal tissue, n = 6. D, E Representative western blot bands and quantitative analyses for tight junction proteins ZO-1, occludin, and claudin-5 in the perihematomal, n = 6. F, G Representative images of double immunofluorescence staining for ZO-1 and GSDMD in the perihematomal tissue 24 h after ICH, n = 6. Scale bar=50 μm. H Evans blue extravasation assay conducted at 24 h following ICH, n = 6. I ELISA for IL-1β and IL-18 levels in the perihematomal tissue, n = 6. *P < 0.05 vs. sham; #P < 0.05 vs. ICH + vehicle.

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