Table 2 Dysregulation of GFPT1 in Cancer.

From: Exploring the metabolic signaling network of GFPT in cancer

GFPT isoform

Cancer type

Expression status

Role in cancer

References

GFPT1/GFPT2

Lung cancer

Upregulation

Tumor growth and survival. Associated with EMT, tumor invasion, migration and metastasis.

[51, 114]

GFPT1/GFPT2

Colon Cancer

Upregulation

Promote EMT tumor growth, invasion and metastasis. Associated with tumor microenvironment and immune infiltration.

[39, 61, 131]

GFPT1/GFP2

Pancreatic ductal Adenocarcinoma (PDA)

Upregulation

Promote tumor aggressiveness lymph node metastasis and stemness. Associated with poor overall survival.

[132, 134, 142, 171]

GFPT1

Glioblastoma

Upregulation

Accelerate growth of tumor and proliferation.

[55]

GFPT1

Prostate Cancer

Upregulation

Tumor proliferation.

[42]

GFPT1

Cervical Cancer

Upregulation

Enhances tumor proliferation.

[97]

GFPT1

Acute Myeloid Leukemia (AML)

Upregulation

Promote proliferation and inhibit cancer cell death.

[91]

GFPT1

Hepatocellular Carcinoma

Upregulation

Promote proliferation, Migration and invasion. Critical for TNM stage and poor overall survival.

[133]

GFPT1

Gastric Cancer

Downregulation

Associated with EMT, invasion and migration.

[162]

GFPT2

Gastric Cancer

Upregulation

Promote tumor invasion and pathological stage. Associated with immune infiltration and poor prognosis.

[148]

GFPT2

Serous Ovarian Cancer

Upregulation

Promote EMT, Cell invasion and migration.

[40]

GFPT2

leiomyosarcoma

Upregulation

Associated with enhanced glucose uptake, c-MYC stability and poor patient outcome.

[52]

GFPT2

Urinary Bladder Cancer (UBC)

Upregulation

Associated with immune infiltration tumor pathological grade and metastasis.

[163]

GFPT2

Breast Cancer

Upregulation

Promote tumor growth, EMT, and stemness. Associated with Claudin low breast cancer.

[140, 154]

Not specified

Cholangiocarcinoma

upregulation

Increases tumor invasion, migration, and EMT.

[62]

  1. GFPT1 has been reported to participate in the progression of different cancer types. Here we list the expression alterations of GFPT1 in diverse cancer types as well as its function in cancer development.
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