Table 1 Role of NLRP3 inflammasome in different diseases.
From: Diverse functions of NLRP3 inflammasome in PANoptosis and diseases
Diseases | Disease and pathologic feature | Role of NLRP3 inflammasome | Ref |
|---|---|---|---|
Autoimmune diseases | |||
Systemic lupus erythematosus (SLE) | Systemic inflammation and dysfunction of multiple organs | Promoting the activation of B cells | [38] |
Rheumatoid arthritis (RA) | Joint pain, swelling and bone destruction | Promoting the differentiation of proinflammatory T cells and inducing the activation of adaptive immune responses | [41] |
Systemic sclerosis (SSc) | Immune dysregulation, endothelial dysfunction and progressive fibrosis | Regulating the activation of macrophages, B cells, Th cells, fibroblasts, and endothelial cells | [45] |
Metabolic diseases | |||
Obesity | Chronic low-grade systemic inflammation | Reducing glucose uptake in insulin-target tissues (such as muscle and adipose tissue) | |
Type 2 diabetes mellitus (T2DM) | Hyperglycemia, hyperlipidemia and insulin resistance (IR) | Reducing glucose uptake in insulin-target tissues (such as muscle and adipose tissue) | |
Atherosclerosis | Atherosclerotic plaque formation | Mediating monocyte/macrophage aggregation and the proliferation of vascular endothelial cells | |
Neurodegenerative diseases | |||
Alzheimer’s disease (AD) | β-amyloid plaque deposition, neurofibrillary tangles (NFTs) formation and chronic neuroinflammation | Regulating the formation of β-amyloid protein and the pathological changes of tau protein, and inducing inflammatory response | |
Parkinson’s disease (PD) | Loss of dopaminergic neurons in the substantia nigra and α-synuclein-containing Lewy bodies | Mediating neuroinflammation, dopamine neuron loss and neurodegeneration | [67] |
Multiple sclerosis (MS) | Oligodendrocyte loss and axons demyelination | Promoting the migration of CD4+ T cells, macrophages, and dendritic cells to the central nervous system (CNS) | [68] |
Fibrotic diseases | Â | Â | Â |
Various organs fibrosis | Excess extracellular matrix (ECM) accumulation and damage of parenchymal cells | Accelerating the expression of fibrosis-related proteins and the deposition of extracellular matrix (ECM); promoting epithelial-mesenchymal transformation (EMT) | |
Cancer | Â | Â | Â |
| Â | / | Complex and context-dependent | [88] |
