Fig. 6: Zharp1-163 alleviates kidney injury in mice. | Cell Death Discovery

Fig. 6: Zharp1-163 alleviates kidney injury in mice.

From: Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

Fig. 6

A–E C57BL/6 mice were intraperitoneally injected with either vehicle or Zharp1-163 (5 mg/kg) for 30 min, followed by an intraperitoneal injection of cisplatin (20 mg/kg) (normal group, n = 7; vehicle group, n = 6; Zharp1-163 group, n = 10). The body weight (A) was monitored for three days. After the experiment, hematoxylin and eosin (H&E) staining (B) of the renal tissue of the mice was performed. Scale bar, 200 μm. C Pathological damage to the kidney was quantified. The levels of creatinine (D) and BUN (E) in mouse serum were measured. F, G. C57BL/6 mice pretreated with vehicle or Zharp1-163 (5 mg/kg) were used to establish a renal I/R injury model (normal group, n = 5; vehicle, Zharp1-163 group, n = 11). The levels of creatinine (F) and BUN (G) in mouse serum were measured. The data are presented as the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

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