Fig. 2: Distinct molecular characteristics of intestinal and diffuse subtypes in gastric cancer. | Cell Death Discovery

Fig. 2: Distinct molecular characteristics of intestinal and diffuse subtypes in gastric cancer.

From: One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer

Fig. 2

A Schematic illustration of patient-derived organoid generation and snRNA-seq analysis. B Uniform Manifold Approximation and Projection (UMAP) plots displayed nine individual clusters from 24,340 single cells. C, D The distribution of annotated cell clusters shown on the UMAP, divided into two subtypes, with each cluster distinguished by clonal samples from the respective subtypes. E The cell proportion of clonal samples and nine clusters of each subtype. F Comparison of KEGG pathway enrichment results for DEGs in each subtype. G Comparison of Hallmark pathway enrichment between the two subtypes using Gene Set Enrichment Analysis (GSEA). H Dotplot of cancer stem cell-related pathway expression between the two subtypes.

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