Fig. 7: Schematic diagram illustrating molecular mechanisms and targeted pathways to enhance therapeutic efficacy in diffuse-like intestinal-type gastric cancer. | Cell Death Discovery

Fig. 7: Schematic diagram illustrating molecular mechanisms and targeted pathways to enhance therapeutic efficacy in diffuse-like intestinal-type gastric cancer.

From: One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer

Fig. 7

Intestinal-type gastric cancer displays intratumoral heterogeneity (ITH), with diffuse-like subpopulations exhibiting high CD44 expression and elevated 1C metabolism. Combining conventional chemotherapy with 1C metabolism targeting results in a synergistic inhibitory effect on tumor growth, offering a promising strategy for CD44-driven GC subtypes (SHIN1:SHMT1/2 inhibitor; DS18561882: MTHFD1/2 inhibitor).

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