Table 2 Mechanisms and signaling pathways of targeted drugs treating GBM through ferroptosis.
From: Ioning out glioblastoma: ferroptosis mechanisms and therapeutic frontiers
Drug | Target | Pathway | Effect | Ref. |
|---|---|---|---|---|
DHA | -GPX4 | -PERK/ATF4/HSPA5 pathway | -GPX4↑ -ATF4↑ | [115] |
RSL3 | -GPX4 | -NF-κB pathway | -GPX4↓ -ATF4↓ -ROS↑ | [74] |
Dihydrotanshinone I | -GPX4 -ACSL4 | -GPX4 and ACSL4 pathway | -GSH/GSSG↓ - GPX4↓ -ACSL4↑ | [81] |
Capsaicin | -ACSL4 -GPX4 | -GPX4 and ACSL4 pathway | -GPX4↓ -ACSL4↑ -GSH↓ | [82] |
Boric acid (BA) | -ACSL4 -GPX4 | -ACSL4/GPx4SEMA3F/NP2 pathways | -GPX4↓ -ACSL4↑ | [83] |
Roxadustat (RXD) | -HIF-α | -lipid peroxidation pathway | -GPX4↓ -4-HNE↑ | [116] |
FSEN1 | -FSP1 | -GSH-GPX4 axis | -GPX4↓ | [78] |
