Fig. 5: Cell characteristics analysis of Ly6C+Ly6G+CD4+ T cells. | Cell Death Discovery

Fig. 5: Cell characteristics analysis of Ly6C+Ly6G+CD4+ T cells.

From: IL-21-dependent Ly6C+Ly6G+CD4+ T cells found in lung enhance macrophages function against Actinobacillus pleuropneumoniae infection in mice

Fig. 5

A–C The transcriptome analysis of Ly6C+Ly6G+CD4+T and Ly6C+Ly6G-CD4+T cells. A The heatmap showing the expression value of indicated genes, B the top 10 KEGG Pathway enrichment in Ly6C+Ly6G+CD4+T cells, C GSEA plots of cytokine-cytokine receptor interaction in Ly6C+Ly6G+CD4+T compared to Ly6C+Ly6G-CD4+T cells. D–L The representative biaxial plots and statistics analysis of (D, E) IL-10, (F, G) IL-21, (H, I) granzyme B, and (J, K) perforin secretion in Ly6C+Ly6G+CD4+ T cells, Ly6C+Ly6G-CD4+ T cells, Ly6C-Ly6G+CD4+ T cells, and Ly6C-Ly6G-CD4+ T cells, respectively. L The expression of CXCR5 in IL-21-Granzyme B-, IL-21+Granzyme B- and IL-21+Granzyme B+ cells of CD4+Ly6C+Ly6G+ cells. *p < 0.05; **p < 0.01; ***p < 0.001, using Mann-Whitney U test. Error bars show means ± SEM.

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